In the new Living Etc, Amanda Holland's home is featured. She uses the large scale wallpaper pattern Rugosa Garden by Designers Guild in her master bath. This pattern definitely has a grandma vibe but she pairs it with Orla Kiely's Striped Petal pattern to keep it fresh and modern (sorry for the iphone pic).
Here are some other favorite nana chic living rooms I found in my Pinterest files. What do you think? Could you rock Nana Chic?